Understanding the mechanisms behind animal transparency holds significance for both fundamental and translational research. However, our comprehension of these mechanisms is currently limited, primarily to a few specialized tissues like the cornea and lenses. Here, I will explore both the mechanisms and broader implications of whole-body transparency using glassfrogs, which are the only known transparent terrestrial vertebrates. These mechanisms include their ability to conceal red blood cells by packing them inside their livers without inducing thrombosis, the utilization of biological mirrors to minimize their body silhouette, and the expression of fluorescent proteins that mimic chlorophyll to aid in modulating their colors and providing photoprotection. Through this investigation, I will leverage amphibian evolution to elucidate fundamental biological processes and inspire innovative approaches in the fields of blood-clot research, metabolism, and the development of optical probes.