The current focus of my lab is biomedical genomics, specifically applications of transcriptomics for personalized medicine. While a Packard Fellow, I helped bring the tools of genome science to studies of development and evolution through the study of quantitative traits, like wing shape in Drosophila. With the revolution in technology that accompanied completion of the human genome a decade ago, I have gradually shifted my interests to human biology. My group is now focused on the integration of genome-wide association studies with gene expression profiling, approaching problems such as how to predict inflammatory bowel disease progression from gene expression profiles, and whether diagnostic yield of pediatric congenital conditions can be improved by RNA sequencing. I also retain an active interest in the evolution of disease risk, particularly around the concepts of canalization and robustness, and how contemporary human behavior influences the maintenance of well-being.