My lab studies the molecular mechanisms of aging and genetic determinants of complex human traits, using system biology approaches that combine quantitative experiments with theoretical modeling and bioinformatics analysis. The lab has developed microfluidic devices to analyze aging at the molecular level in single cells and genetic systems for high throughput lifespan screening. The lab has also developed various computational algorithms to analyze gene regulatory networks, and more recently to map genes that influence complex human traits by combining genome-wide association studies with other large-scale molecular trait data.