My laboratory investigates the role of RNA in biological processes using structural and biophysical methods. Our goal is to obtain a combined structural and dynamic view of how RNAs control biological processes, such as translation and viral replication, with a long-term goal of targeting disease processes involving RNA.
My lab focuses on: (1) understanding how gene regulatory networks encode and decode information to control gene expression; and (2) investigating the function and mechanism of oscillation of a three-protein circadian clock. In a new project, we are studying the mechanism of drug action, making use of a human cell line amenable to loss of … Continued
I am Chief Scientific Officer, mRNA Research Platform at Moderna Therapeutics, where I am responsible for leading all mRNA biology research at Moderna. My previous research at UMass encompassed a broad array of topics related to the role of RNA and RNA-protein (RNP) complexes in gene expression and touched on many human diseases including cancer, … Continued
Our group investigates the Conformational – Functional Behavior of Proteins. The approach we use is multidisciplinary, borrowing concepts and methodologies from condensed matter physics, physical chemistry,molecular spectroscopy, computer science, protein chemistry, and molecular and cell biology. We employ kinetic techniques (stopped-flow, continuous flow, temperature-jump), steady state spectroscopy (fluorescence, absorption, circular dichroism), nuclear magnetic resonance, single … Continued
The focus of my lab is the coupling of theoretical, computational, and experimental techniques for the study of structural biology. In particular, we have placed a major emphasis on developing quantitative methods for protein design with the goal of developing a fully systematic design strategy that they call “protein design automation.” Our design approach has … Continued
A long-term goal of the Marcotte lab is to understand the regulation and organization of the human proteome—the >20,000 proteins encoded within humans’ genomes—especially how these proteins’ abundances, interactions, and spatial distributions are dynamically controlled. Such data help reveal the functions of these proteins, nearly a quarter of which are still mostly uncharacterized. The lab … Continued
The Kelleher laboratory has evolved into three main sub-groups working in the areas of Top Down Proteomics, Natural Products Biosynthesis/Discovery, and Chromatin Biology. The core of the group is built around expertise in technology development for complex mixture analysis using Fourier-Transform mass spectrometry (FTMS) for targeted applications in proteomics and natural products chemistry, devising technologies … Continued
Research in the Jarrett Lab focuses on understanding the chemical mechanisms of reactions catalyzed by enzymes, with a particular focus on enzymes that employ organic radicals as reactive intermediates. Biotin synthase is a radical enzyme that adds a sulfur atom to complete the biosynthesis of this important cofactor; our work has shown that the enzyme … Continued
My research group aims to understand how ion channels and transporters function at the atomic level through the use of structure biology and electrophysiology. Specifically, we seek to elucidate the basic principles of channel regulation and ion selectivity among tetrameric cation channels, the largest ion channel family whose functions are central to nerve excitation, muscle … Continued
The overarching goal of my lab is to understand the fundamental behavior of RNA and proteins and, in turn, how these behaviors determine and impact biology more broadly. We are particularly interested in questions of how enzymes work, how RNA folds, how proteins recognize RNA, and the roles of RNA/protein interactions in regulation and control, … Continued