My laboratory works at the combined interface of chemistry, biology, medicine, and biotechnology. The lab seek to understand the fundamental chemistry that controls cellular interactions between and among proteins, nucleic acids, and small molecules, and then apply this knowledge to discover new biology or develop novel molecules with unique and useful properties. Current topics include … Continued
The focus of my research is the direct time-domain study of chemical reactions and photophysical processes in condensed media and at interfaces. My interest is the elucidation of the microscopic dynamics of the reactant and the role of the solvent (or interface) through the development and application of new spectroscopic methods.
Research in my group lies at the intersection of surface chemistry and nanotechnology. In virtually all material systems, the most important chemical and physical processes occur at the interfaces between distinct materials. In my laboratory, precision chemical interfaces are fabricated, and dynamic structural and electronic features are explored for prospective energy, environmental and nanoelectronic applications. … Continued
My research focuses on fundamental studies of nanoscale electrical, optical, and plasmonic devices that operate based upon quantum mechanical principles as well as the development of new nano- and microelectronic tools that can interface with living cells, cell networks, and organisms. The goal of our quantum optoelectronics effort is to develop solid-state photonic, optoelectronic, and … Continued
My research interests encompass three different areas. In catalysis, my group is developing new catalysts for organic synthesis and polymer synthesis, especially those that employ supramolecular and biomimetic principles. We are also exploring catalytic processes that involve extended systems–such as artificial enzymes, solid-state catalysts (MOF, POP, supported oxide), and multiple-phase systems–and elucidating their mechanisms of … Continued
In the decades ahead, the challenges that face the field of chemical synthesis lie in the discovery and design of novel, more efficient, waste-free synthetic protocols that provide rapid assembly of complex molecular architectures from inexpensive chemical feedstocks. New advances in chemical catalysis are crucial to fulfilling this objective and could offer solutions to long-standing … Continued
My laboratory focuses on the discovery, biosynthesis, and structural/functional characterization of novel natural products. Through a combination biosynthetic knowledge and genomics analysis, pathways that are most likely to produce chemically and biologically interesting molecules can be prioritized. Our lab also develops methods to predict organic functional groups within natural products to facilitate their discovery by … Continued
Our research is focused on the development of new processes and on studying their utility in complex molecule synthesis. Control of enantioselectivity is an overarching theme as adequate control of molecular shape is paramount in the design of effective therapeutics, materials, and commodity chemicals. Progress towards these goals depends upon expertise in many areas of … Continued
I am interested in chemical synthesis directed toward amelioration of problems in human health.
The Mazziotti group pursues research in many-electron theory and computation to advance our ability to understand and predict molecular structure and processes.